Weight Management & Metabolism

Focus Area #3: Oxidative Stress and Metabolic Health

Oxidative stress plays a significant yet often underappreciated role in metabolic health and glucose metabolism challenges. When the body metabolizes glucose for energy, particularly in the presence of elevated blood sugar levels, it generates reactive oxygen species (free radicals) as byproducts. Under normal circumstances, the body's antioxidant defense systems neutralize these free radicals. However, when blood sugar levels are frequently elevated or when metabolic function is compromised, oxidative stress increases—free radical production exceeds the body's ability to neutralize them. This oxidative stress has multiple negative consequences for metabolic health including damage to pancreatic beta cells (which produce insulin), impaired insulin signaling in muscle, fat, and liver cells, increased inflammation contributing to insulin resistance, damage to blood vessels affecting circulation, cellular damage accelerating aging processes, and contributing to the development and progression of metabolic concerns. The relationship between oxidative stress and metabolic health is bidirectional—elevated blood sugar increases oxidative stress, and oxidative stress further impairs glucose metabolism and insulin function, creating a damaging cycle. Beyond glucose-related oxidative stress, modern life generates additional free radicals through environmental pollution, UV radiation, processed foods, stress, inadequate sleep, and other factors. Metabolic health requires not just supporting glucose metabolism and insulin function but also protecting cells and tissues from oxidative damage through adequate antioxidant support. Many people focus exclusively on glucose and insulin when thinking about metabolic health, overlooking the critical importance of antioxidant protection.

How PranaBolt Blood Sugar Support May Help:

This antioxidant-enhanced formula recognizes the crucial role of oxidative stress in metabolic health by including powerful antioxidants alongside glucose metabolism supporters.* Alpha Lipoic Acid deserves special attention—it's both a powerful antioxidant and a key compound in glucose metabolism, making it uniquely valuable for metabolic support.* Alpha lipoic acid is unusual because it's both water-soluble and fat-soluble, allowing it to work throughout the body in various cellular compartments.* Research has extensively investigated alpha lipoic acid for its antioxidant properties, its ability to regenerate other antioxidants (including vitamins C and E, and glutathione), and its potential to support insulin sensitivity and glucose metabolism.* Studies have explored alpha lipoic acid for its potential to reduce oxidative stress associated with metabolic challenges, support healthy nerve function, and promote overall metabolic wellness.* Vitamin E (as d-alpha tocopheryl acetate) is the primary fat-soluble antioxidant protecting cell membranes and lipoproteins from oxidative damage—vitamin E is particularly important for protecting against lipid peroxidation, which is elevated in metabolic dysfunction.* Research has investigated vitamin E's role in supporting insulin sensitivity and protecting pancreatic beta cells.* Vitamin C (as ascorbic acid) is a powerful water-soluble antioxidant that works synergistically with vitamin E—vitamin C can regenerate vitamin E after it has neutralized free radicals, extending vitamin E's antioxidant protection.* Vitamin C also supports healthy blood vessels, immune function, and overall cellular health.* Zinc (zinc oxide) and Manganese (manganese amino acid chelate) are essential mineral cofactors for antioxidant enzymes including superoxide dismutase—one of the body's primary enzymatic antioxidant defense systems.* Without adequate zinc and manganese, these critical antioxidant enzymes cannot function optimally.* Cayenne Pepper Extract (fruit) contains capsaicin and other compounds that research has investigated for antioxidant properties, potential metabolic benefits, and circulatory support.* The botanical ingredients including Bitter Melon, Cinnamon, Gymnema Sylvestre, Banaba, Yarrow, Juniper Berry, and Mulberry all contain various polyphenolic compounds and phytonutrients that provide additional antioxidant activity beyond their direct glucose metabolism effects.* Deglycyrrhizinated Licorice Extract (root) provides beneficial compounds without the glycyrrhizin that can affect blood pressure in regular licorice, offering antioxidant and other supportive properties.* This comprehensive antioxidant network helps protect pancreatic cells, support healthy insulin signaling, reduce inflammation associated with metabolic stress, protect blood vessels and circulation, and support overall cellular health and metabolic function.* By addressing oxidative stress alongside glucose metabolism, this formula provides more comprehensive metabolic support than products focusing on glucose metabolism alone.*

Focus Area #4: Age-Related Metabolic Changes

Aging naturally affects metabolic function and glucose metabolism, with metabolic efficiency typically declining as people age. Multiple age-related changes impact glucose metabolism including progressive decrease in insulin sensitivity (cells become less responsive to insulin's signals), decline in pancreatic beta cell function (reducing insulin production capacity), changes in body composition with increased fat mass and decreased muscle mass (muscle is highly insulin-sensitive, so losing muscle impairs glucose metabolism), reduced physical activity levels affecting insulin sensitivity and glucose utilization, hormonal changes affecting metabolism, increased inflammation (inflammaging), accumulated oxidative damage, and medication effects (many medications affect glucose metabolism). These changes mean that blood sugar levels that were easily maintained in younger years may become more challenging to keep within healthy ranges as people age, even without major lifestyle changes. Research shows that insulin sensitivity declines by approximately 10-15% per decade after age 40, and metabolic rate decreases with age, making weight management more challenging. Many adults notice that maintaining healthy blood sugar levels, energy levels, and body weight becomes progressively more difficult with each passing decade despite maintaining similar diet and exercise patterns. Age-related metabolic changes contribute to increased risk of various health concerns, reduced energy and vitality, difficulty maintaining healthy weight, changes in body composition, and decreased quality of life. While aging is inevitable, supporting metabolic health through nutrition, exercise, stress management, sleep, and strategic supplementation can help maintain better metabolic function and support healthy aging.

How PranaBolt Blood Sugar Support May Help:

This age-friendly metabolic formula provides comprehensive nutritional support specifically relevant to maintaining healthy glucose metabolism during the aging process.* Chromium becomes increasingly important with age—research suggests that chromium status may decline with aging, and chromium's role in supporting insulin sensitivity becomes more critical as natural insulin sensitivity decreases.* Studies have specifically investigated chromium supplementation in older adults for supporting glucose metabolism and insulin function.* Alpha Lipoic Acid has been extensively studied for its potential to support healthy aging processes, protect against oxidative stress that accumulates with age, support mitochondrial function (cellular energy production declines with age), and help maintain insulin sensitivity.* Research has investigated alpha lipoic acid for supporting various aspects of healthy aging.* Magnesium is often insufficient in older adults' diets, and magnesium deficiency can impair insulin function—ensuring adequate magnesium supports healthy glucose metabolism and insulin sensitivity that tend to decline with age.* Zinc is important for immune function, which becomes more important with aging, and for supporting insulin production and function.* The comprehensive botanical blend provides traditional wisdom combined with modern research—many of these botanicals have long histories of traditional use for supporting metabolic wellness and healthy aging.* Bitter Melon, Gymnema Sylvestre, and Banaba have all been traditionally used in various cultures for supporting metabolic health, particularly in older adults.* Antioxidants (Vitamin C, Vitamin E, Alpha Lipoic Acid, and antioxidant compounds in the botanical extracts) become increasingly important with age to counter the accumulated oxidative damage and increased oxidative stress associated with aging.* Taurine levels decline with age, and research has investigated taurine supplementation for supporting various aspects of healthy aging including metabolic health.* Mulberry Fruit Powder has been traditionally used and studied for glucose metabolism support, with research exploring its potential benefits for maintaining healthy blood sugar levels.* Juniper Berry and Yarrow Herb Powder provide additional botanical support with traditional use for overall wellness.* By providing this comprehensive nutritional support, the formula helps address multiple aspects of age-related metabolic changes—supporting insulin sensitivity, providing antioxidant protection, supporting pancreatic function, and promoting overall metabolic wellness throughout the aging process. While this supplement provides valuable support, it works best alongside age-appropriate lifestyle practices including regular physical activity emphasizing both cardiovascular exercise and strength training to maintain muscle mass, balanced nutrition with adequate protein and fiber, stress management, quality sleep, social engagement, cognitive stimulation, and regular health monitoring with healthcare providers.*

Understanding the Top 4 Pain Points

Pain Point #1: Low Mood and Emotional Challenges

Persistent low mood affects millions of people, creating a heavy emotional burden that impacts every aspect of life. While clinical Emotional well-being requires professional treatment, many individuals experience subclinical mood concerns—feelings of being "down," lacking enthusiasm, experiencing emotional flatness, or struggling with general unhappiness that doesn't rise to the level of diagnosed Emotional well-being but still significantly affects quality of life.

The serotonin connection to mood has been extensively studied. While the relationship is complex and not fully understood, research has established that serotonin plays important roles in mood regulation*. Low serotonin levels have been associated with mood challenges*, though it's important to note that mood is influenced by multiple neurotransmitters, hormones, life circumstances, and other factors—not serotonin alone.

Modern lifestyle factors may affect serotonin synthesis. Occasional stress depletes neurotransmitter reserves, inadequate dietary protein reduces available amino acid precursors, poor sleep disrupts neurotransmitter production cycles, and sedentary behavior affects various biochemical processes* including potentially serotonin metabolism. These accumulated modern stressors create conditions where the body's natural serotonin production* may not meet demand.

The emotional well-being impact of suboptimal serotonin extends beyond just "feeling sad." People describe feeling emotionally fragile, reactive to minor stressors, unable to experience joy in activities they once enjoyed, struggling with irritability, and generally feeling that life lacks color and vibrancy. This emotional flatness affects relationships, work performance, self-care motivation, and overall life satisfaction.

Treatment concerns and preferences influence supplement interest. Prescription antidepressants, while effective for many, come with potential side effects, require ongoing medical management, and may not be necessary or appropriate for subclinical mood concerns. Many individuals prefer trying natural approaches first*, particularly for mild mood support*, before considering pharmaceutical interventions.

The search for balance drives interest in natural mood support*. While serious mood disorders require professional care, those experiencing mild mood fluctuations or seeking proactive mood wellness support* may find value in supplements that support the body's natural neurotransmitter production*. The goal is maintaining emotional balance and resilience* rather than treating disease.

Finding natural approaches that support the body's serotonin production* addresses the need for mood wellness support* while respecting the body's natural biochemistry and offering a gentler first-line approach for those with mild mood concerns.

Pain Point #2: Sleep Difficulties and Disrupted Rest Patterns

Sleep problems are epidemic in modern society, with millions struggling to fall asleep easily, stay asleep through the night, achieve restorative deep sleep, or wake feeling refreshed. Poor sleep affects every aspect of health and functioning—mood, cognitive performance, immune resilience, metabolic health, and overall quality of life all suffer when sleep is inadequate or poor quality.

The serotonin-sleep connection is well-established through research. Serotonin serves as a precursor to melatonin, the primary sleep-regulating hormone. When serotonin levels are adequate, the body can convert appropriate amounts to melatonin* when darkness signals it's time for sleep. Insufficient serotonin may therefore affect the body's ability to produce adequate melatonin* and maintain healthy sleep-wake cycles*.

Multiple sleep challenges affect different individuals. Some struggle primarily with sleep onset—lying awake unable to quiet racing thoughts and relax into sleep. Others fall asleep easily but wake frequently during the night or too early in the morning. Some experience non-restorative sleep—spending adequate time in bed but waking feeling unrefreshed. Each pattern may involve different underlying mechanisms, but serotonin's role in sleep regulation* means supporting adequate levels may benefit various sleep concerns*.

The modern sleep crisis stems from lifestyle factors that disrupt natural sleep patterns. Blue light from screens suppresses melatonin production, irregular schedules confuse circadian rhythms, stress keeps the nervous system activated when it should be winding down, and stimulants consumed too late affect sleep quality. These factors all potentially impact the serotonin-melatonin pathway* that regulates healthy sleep.

The cumulative effects of poor sleep extend far beyond tiredness. Occasional sleep deprivation impairs immune function, disrupts appetite regulation and metabolism, affects emotional regulation (making people more irritable and reactive), impairs cognitive function and memory, and increases risk for various health concerns. The desperation for quality sleep drives interest in any safe intervention that might help.

Natural sleep support preferences lead many to explore supplements before stronger pharmaceutical sleep medications. While prescription sleep aids have their place, they often come with side effects including next-day grogginess, dependency risks, and simply not feeling like "natural sleep." Those seeking to support their body's natural sleep processes* may prefer approaches that work with—rather than override—the body's own sleep-regulation systems.

Finding natural support for the serotonin-melatonin pathway* that regulates healthy sleep cycles addresses the widespread need for better rest without the concerns associated with stronger sleep medications, particularly for those with mild to moderate sleep challenges.

Pain Point #3: Appetite Dysregulation and Emotional Eating

Appetite control challenges affect millions struggling with food cravings, emotional eating, inability to feel satisfied despite eating, constant thoughts about food, or difficulty maintaining healthy eating patterns. While appetite is influenced by numerous factors—hormones, blood sugar, habits, emotions, environment—serotonin plays a recognized role in appetite regulation* and satiety signaling*.

The serotonin-appetite link has been studied extensively. Research has found that serotonin appears to promote feelings of satiety* (satisfaction after eating) and may influence food preferences*. Low serotonin levels have been associated with increased carbohydrate cravings*, particularly for simple carbs and sweets. This connection helps explain why mood and appetite often seem linked—the same neurotransmitter affects both.

Emotional eating patterns create frustrating cycles. Stress, occasional stress, sadness, or boredom trigger urges to eat—not from physical hunger but for emotional comfort. The temporary mood boost from eating (particularly carbohydrates, which may briefly increase serotonin*) reinforces the pattern, creating psychological and potentially biochemical associations between emotions and eating that become difficult to break.

Carbohydrate cravings specifically may have biochemical underpinnings beyond just "lack of willpower." When serotonin is low, the body may crave carbohydrates* because consuming them triggers insulin release, which affects amino acid transport in ways that temporarily increase tryptophan availability to the brain and subsequent serotonin production*. This creates a self-medication pattern where people instinctively reach for carbs when serotonin needs support.

Weight management implications make appetite regulation important for many. Excess calorie consumption driven by inadequate satiety signals, emotional eating, or constant cravings contributes to weight gain that affects health, mobility, confidence, and quality of life. While supplements alone don't cause weight loss, supporting healthy appetite regulation* may help some individuals better adhere to appropriate eating patterns as part of comprehensive lifestyle approaches.

The cycle-breaking challenge frustrates those trying to establish healthier eating patterns. When biochemical factors (like potentially low serotonin) drive cravings and eating behaviors, willpower alone often proves insufficient. Addressing underlying neurochemical aspects* may help create conditions where healthier choices become more manageable and sustainable.

Finding natural support for serotonin levels that play a role in appetite regulation* addresses one piece of the complex appetite puzzle, potentially helping some individuals better manage cravings and emotional eating patterns* as part of comprehensive wellness approaches.

Pain Point #4: Stress, occasional stress, and Emotional Overwhelm

Occasional stress and occasional stress have become defining features of modern life. The constant pressure of work demands, financial concerns, relationship challenges, health worries, and the relentless pace of contemporary existence create sustained psychological stress that affects mental, emotional, and physical well-being. While clinical occasional stress disorders require professional treatment, many people experience subclinical occasional stress—persistent worry, tension, emotional reactivity, and stress intolerance that impacts quality of life.

The neurotransmitter connection to stress resilience involves multiple brain chemicals, with serotonin playing a recognized role. Research has found that adequate serotonin appears to support emotional regulation*, help buffer stress responses*, and contribute to overall stress resilience*. Conversely, low serotonin has been associated with increased occasional stress* and reduced ability to cope with stressors.

The stress-serotonin cycle can become self-perpetuating. Occasional stress may deplete serotonin and other neurotransmitters, while low serotonin reduces stress resilience*, making individuals more vulnerable to stress impacts. This creates a downward spiral where stress worsens neurochemistry, which in turn reduces capacity to handle stress, leading to more stress impacts.

Physical manifestations of stress and occasional stress affect daily life significantly. Muscle tension, headaches, digestive distress, sleep disruption, fatigue, difficulty concentrating, and feeling "on edge" or unable to relax all stem from overactive stress responses. These physical symptoms themselves create additional stress, compounding the problem.

The functioning impact of occasional stress and emotional overwhelm affects work performance, relationships, social engagement, and self-care capacity. When occasional stress is high, decision-making becomes impaired, concentration suffers, interpersonal interactions feel more difficult, and even basic tasks can feel overwhelming. The reduced functioning itself becomes a source of distress and frustration.

Coping strategy limitations lead to interest in additional support. While stress management techniques—meditation, exercise, therapy, sleep hygiene, and lifestyle modifications—are essential and effective, many people seek additional biochemical support*, particularly natural options that may help the body better manage its stress responses* without the side effects of pharmaceutical anxiolytics.

Finding natural support for neurotransmitter levels involved in stress resilience and emotional regulation* addresses the need for additional tools in managing modern life's unavoidable stresses, potentially helping maintain better emotional balance* and stress coping capacity*.

How ShantiMoon 5-HTP Provides Support*

Natural Mood Support Through Serotonin Precursor*

5-HTP's mechanism as a direct precursor to serotonin provides straightforward biochemical support. When you consume 5-HTP, it crosses the blood-brain barrier and is converted to serotonin in the brain*, offering direct support for serotonin synthesis*. Research published in Alternative Medicine Review examined 5-HTP's role in supporting mood*, finding evidence for its effectiveness in various studies.

Multiple research studies have examined 5-HTP for mood support. A review in Neuropsychiatric Disease and Treatment examined clinical trials finding that 5-HTP supplementation was associated with improvements in mood parameters* in various populations. While more research is needed and individual responses vary, the evidence supports 5-HTP's potential role in mood wellness*.

The natural approach appeals to those preferring to work with the body's existing pathways. Rather than artificially manipulating neurotransmitter activity (as some pharmaceuticals do), 5-HTP provides a building block the body naturally uses*, allowing the body's own regulatory systems to convert it to serotonin as needed*. This respects the body's wisdom while providing support where synthesis may be inadequate.

Griffonia simplicifolia sourcing provides botanical origin for the 5-HTP, derived from the seeds of this African plant naturally high in this compound. This plant-based sourcing creates an extract that provides 5-HTP in forms the body recognizes*, rather than synthetic alternatives.

Calcium's supporting role shouldn't be overlooked—this mineral supports various neurological functions* including nerve signal transmission*, contributing to the formula's comprehensive support for nervous system wellness*.

Individual responses vary significantly, with some people noticing mood improvements* within weeks while others may need longer or may not respond as robustly. Factors including baseline serotonin status, diet, stress levels, sleep quality, exercise, and genetic variations all influence outcomes. Consistent use over 4-12 weeks typically provides the best assessment of individual response.

By providing direct serotonin precursor support through naturally-sourced 5-HTP, ShantiMoon addresses one of the biochemical factors that may affect mood, offering natural support for emotional well-being.

Sleep Quality Support Through the Serotonin-Melatonin Pathway*

The serotonin-to-melatonin conversion is a well-established biochemical pathway. Serotonin serves as the precursor to melatonin—the pineal gland converts serotonin to melatonin* in response to darkness signals. When serotonin levels are adequate, this conversion can proceed efficiently*, supporting healthy melatonin production* and sleep-wake cycle regulation*.

Research on 5-HTP and sleep has examined its potential to support sleep quality. Studies have found that 5-HTP supplementation may help support healthy sleep patterns*, possibly through its role in melatonin production* as well as serotonin's own involvement in sleep architecture and REM sleep regulation*.

The timing consideration for sleep support often involves evening dosing, though individual responses vary. Some practitioners suggest taking 5-HTP earlier in the day to allow time for serotonin production that will later convert to melatonin at night*, while others recommend evening use closer to bedtime. Individual experimentation under healthcare provider guidance may help identify optimal timing.

Sleep architecture effects may extend beyond just falling asleep. Serotonin appears to play roles in sleep cycle regulation*, including REM sleep which is crucial for emotional processing and memory consolidation. Supporting adequate serotonin* may therefore contribute to more restorative sleep quality*, not just sleep quantity.

The non-sedating approach distinguishes 5-HTP from direct sleep aids. Rather than forcing sleep through sedation, 5-HTP supports the body's natural sleep regulation processes* by providing precursors for the neurotransmitters involved in healthy sleep-wake cycles*. This may result in more natural-feeling sleep that doesn't create morning grogginess.

Complementary practices enhance 5-HTP's sleep benefits*. Good sleep hygiene—consistent schedules, darkness at night, screen reduction before bed, stress management—works synergistically with serotonin support* to optimize sleep quality. The supplement addresses biochemical aspects while lifestyle factors address behavioral and environmental influences.

By supporting adequate serotonin production that can convert to melatonin, ShantiMoon 5-HTP may help promote healthy sleep patterns and sleep quality as part of comprehensive sleep wellness approaches.

Appetite Regulation and Satiety Support*

Serotonin's role in appetite regulation has been documented in numerous studies. Research published in journals including Nutrition Reviews has examined how serotonin affects eating behaviors, finding that it appears to promote satiety*, influence meal termination*, and potentially affect food preferences* particularly regarding carbohydrates.

The carbohydrate craving connection to serotonin provides a plausible mechanism for how 5-HTP might help. Studies suggest that low serotonin may be associated with increased carbohydrate cravings*, particularly for simple carbs and sweets. By supporting adequate serotonin levels*, 5-HTP supplementation may help reduce these specific cravings* in some individuals.

Satiety signaling support means feeling appropriately satisfied after eating rather than continuing to feel hungry or experiencing persistent food thoughts despite adequate calorie consumption. Research has examined serotonin's role in signaling satiety to the brain*, suggesting that supporting adequate serotonin* may help improve satiety perception* in some individuals.

Emotional eating patterns may be influenced by serotonin status since mood and appetite are interconnected through serotonin. When mood improves with better serotonin support*, the emotional eating triggers driven by attempts to self-medicate mood through food may diminish*, potentially helping individuals better distinguish physical hunger from emotional eating urges.

Important limitations must be acknowledged—5-HTP is not a weight loss supplement and shouldn't be used primarily for that purpose. While some research has examined 5-HTP for effects on eating patterns*, results are mixed and individual responses vary greatly. Any appetite effects should be viewed as a potential secondary benefit that may help some individuals better adhere to healthy eating patterns as part of comprehensive approaches.

Professional guidance is particularly important when using supplements for appetite-related concerns, as eating issues can be complex and sometimes indicate underlying conditions requiring appropriate care. 5-HTP should be part of—not a replacement for—comprehensive approaches to healthy eating.

By potentially supporting appetite regulation and satiety through serotonin's known roles in eating behavior, ShantiMoon 5-HTP may help some individuals better manage appetite and cravings as one component of holistic wellness approaches.

Stress Resilience and Emotional Balance Support*

Serotonin's role in stress response has been extensively studied. Research has found that adequate serotonin appears to help modulate the body's stress response systems*, support emotional regulation*, and contribute to overall stress resilience*. Conversely, low serotonin has been associated with increased stress reactivity* and reduced coping capacity.

The emotional regulation aspect is particularly relevant. Serotonin appears to help maintain emotional stability* and appropriate emotional responses to situations. When levels are adequate, individuals may feel better able to handle daily stressors*, maintain perspective during challenges*, and recover more quickly from emotional upsets*.

Research on 5-HTP for stress has examined its potential to support stress management. Studies have found that 5-HTP supplementation may help support healthy stress responses* and promote emotional well-being* during stressful periods. While it doesn't support reduction of stress or occasional stress (which sometimes serve protective functions), it may help the body manage these responses more adaptively*.

The occasional stress-serotonin connection has strong research support. Multiple studies have examined the relationship between serotonin function and occasional stress, finding that supporting adequate serotonin* may help maintain emotional calm* and reduce excessive worry or tension* in some individuals. This makes 5-HTP potentially valuable for subclinical occasional stress management*.

Comprehensive stress management requires multiple approaches—lifestyle modifications, stress reduction techniques, adequate sleep, exercise, social support, and professional help when needed. 5-HTP addresses the neurochemical component*, providing biochemical support that may enhance the effectiveness of other stress management strategies.

Individual variations in response to 5-HTP for stress are significant. Factors including baseline serotonin status, stress severity, concurrent health conditions, medications, and genetic factors all influence outcomes. What provides substantial benefit for one person may offer modest or no benefit for another, making individual assessment essential.

By supporting adequate serotonin levels that play crucial roles in emotional regulation and stress resilience, ShantiMoon 5-HTP may help promote better stress coping capacity and emotional balance* as part of comprehensive stress wellness approaches.

Complete Ingredient Profile

Active Ingredients:

• 5-Hydroxytryptophan (5-HTP) from Griffonia simplicifolia Seed Extract – Direct precursor to serotonin; supports serotonin synthesis in the brain*; may help promote mood balance*, support sleep quality*, help maintain healthy appetite regulation*, and contribute to stress resilience*; naturally derived from African plant seeds

Supporting Nutrients:

• Calcium (as Calcium Carbonate) – Essential mineral; supports bone health*; contributes to healthy nervous system function*; involved in neurotransmitter release*; supports muscle function*

Inactive Ingredients:

• Gelatin (capsule) – Capsule material derived from animal sources; protects ingredients and facilitates swallowing
• Magnesium Stearate – Vegetable-derived flow agent; prevents ingredients from sticking to manufacturing equipment; ensures consistent dosing

Product Specifications:

• Form: Capsules
• Count: 60 capsules per bottle
• Serving Size: 2 capsules
• Servings Per Container: 30
• Manufacturing: USA
• Capsule Type: Gelatin (not suitable for vegetarians/vegans)

Dosage Information:

• Suggested Use: Take 2 capsules once daily
• Timing: 20-30 minutes before a meal with 8oz (236ml) water
• Frequency: Once per day
• Duration: Consistent use over 4-12 weeks for optimal assessment

Important Notes:

• Not for children under 18
• Consult healthcare provider if pregnant, nursing, or have medical conditions
• Do not exceed recommended dose
• Not suitable for vegetarians (gelatin capsules)

Why Choose ShantiMoon 5-HTP?

1. Natural Serotonin Precursor Provides 5-HTP directly rather than requiring conversion from L-tryptophan, offering more efficient support for serotonin synthesis*.

2. Griffonia Simplicifolia Source Derived from natural botanical source rather than synthetic production, providing plant-based 5-HTP.

3. Comprehensive Mood Support Addresses multiple wellness areas including mood, sleep, appetite, and stress resilience through serotonin support.

4. Research-Backed Ingredient Extensive scientific literature examines 5-HTP's potential benefits* for various aspects of emotional and mental wellness*.

5. Clean, Simple Formula Straightforward ingredient list without unnecessary fillers, additives, or proprietary blends—just 5-HTP with calcium support.

6. Made in USA Domestic manufacturing ensures quality oversight and adherence to dietary supplement manufacturing standards.

7. Convenient Once-Daily Dosing Simple regimen of 2 capsules once daily makes consistent supplementation easy to maintain.

8. Affordable Wellness Support Provides one-month supply at accessible price point for those seeking natural mood and wellness support*.

9. Holistic Approach Supports the body's *natural neurotransmitter production rather than artificially manipulating brain chemistry.

10. Versatile Benefits May help with multiple wellness concerns including mood, sleep, appetite, and stress through single supplement.

How to Use for Optimal Results

Standard Dosage: Take 2 capsules once daily as a dietary supplement.

Timing Recommendations: 20-30 minutes before a meal with 8oz (236ml) glass of water, or as directed by healthcare professional.

Best Time of Day:

• Evening: Many users take in evening to support overnight serotonin-to-melatonin conversion* for sleep support
• Morning/Daytime: Others prefer earlier dosing to support mood throughout the day
• Individual experimentation: Under healthcare provider guidance, find timing that works best for your goals

With or Without Food: The suggested timing is before meals, but taking with food may reduce any potential digestive sensitivity in those with sensitive stomachs.

Consistency is Key: Daily, regular use over 4-12 weeks provides the best assessment of individual response. Benefits may emerge gradually rather than immediately.

Important Guidelines:

• Do not exceed 2 capsules daily unless directed by healthcare professional
• Not for children under 18 years of age
• Pregnant or nursing women must consult healthcare provider before use
• Those with medical conditions or taking medications should consult healthcare provider, particularly if taking antidepressants, anti-occasional stress medications, or other serotonergic drugs

Usage Tips for Maximum Benefits

1. Be Patient with Results 5-HTP effects may take 4-12 weeks of consistent use to fully manifest. Don't expect immediate dramatic changes—benefits often emerge gradually.

2. Maintain Consistent Schedule Take at the same time daily to maintain steady support for serotonin synthesis* and establish a routine that's easy to remember.

3. Combine with Healthy Lifestyle 5-HTP supports—not replaces—healthy diet, adequate sleep, regular exercise, stress management, and social connections. Synergistic effects emerge when supplements complement healthy habits.

4. Consider Vitamin B6 Some practitioners suggest concurrent B6 supplementation as it's a cofactor in serotonin synthesis, though discuss with healthcare provider first to avoid excessive intake.

5. Monitor Individual Response Track mood, sleep quality, appetite, and stress levels to understand your personal response and determine if the supplement is beneficial for you.

6. Avoid Certain Combinations Never combine with prescription antidepressants (SSRIs, SNRIs, MAOIs) or other serotonergic medications without explicit healthcare provider approval—dangerous serotonin syndrome can result.

7. Stay Hydrated Adequate water intake supports overall supplement absorption and wellness, particularly when taking capsules.

8. Consider Timing Adjustments If experiencing sleep benefits but daytime drowsiness, try taking later in day. If sleep isn't improving, try earlier dosing to allow serotonin buildup during day.

9. Don't Use Long-Term Without Assessment Periodically assess (with healthcare provider) whether continued supplementation is beneficial, or if lifestyle modifications have addressed underlying issues.

10. Discontinue Before Surgery Stop taking 5-HTP at least 2 weeks before scheduled surgery as it may interact with anesthesia or other surgical medications.

Quality & Safety Information

Manufacturing Standards: ShantiMoon 5-HTP is manufactured in the USA in facilities following Good Manufacturing Practices (GMP) for dietary supplements.

Safety Guidelines:

Not for Everyone:

• Not for children under 18 years of age
• Pregnant or nursing women must consult healthcare provider
• Individuals with medical conditions should consult physician before use

Critical Drug Interactions: 5-HTP can cause dangerous interactions with:

• Antidepressants (SSRIs, SNRIs, MAOIs, tricyclics)
• Anti-occasional stress medications
• Migraine medications (triptans)
• Pain medications (tramadol, meperidine)
• Carbidopa (Parkinson's medication)
• Any serotonergic drug

Serotonin Syndrome Warning: Combining 5-HTP with medications that affect serotonin can cause serotonin syndrome—a potentially life-threatening condition. Symptoms include confusion, agitation, rapid heart rate, high blood pressure, dilated pupils, muscle rigidity, and fever. Never combine without healthcare provider approval.

Potential Side Effects: Generally well-tolerated when used appropriately. Some individuals may experience:

• Nausea or digestive discomfort (often resolves with continued use or taking with food)
• Drowsiness (adjust timing if this occurs)
• In rare cases, vivid dreams or diarrhea

Pre-Surgery Precaution: Discontinue use at least 2 weeks before surgery as 5-HTP may interact with anesthesia.

Storage: Store in a cool, dry place. Do not use if safety seal is damaged or missing. Keep out of reach of children.

Who Will Benefit from This Product?

Mood Wellness Seekers: Those experiencing mild low mood or emotional flatness who want natural support for mood balance* and emotional well-being*.

Sleep Quality Improvers: Individuals with mild to moderate sleep difficulties seeking natural support for healthy sleep patterns* through the serotonin-melatonin pathway*.

Appetite Management Support: People struggling with carbohydrate cravings, emotional eating, or inadequate satiety who want to support healthy appetite regulation*.

Stress Resilience Builders: Those experiencing Occasional stress or subclinical occasional stress seeking natural support for emotional balance* and stress coping capacity*.

Natural Wellness Advocates: Consumers preferring natural, botanical-derived supplements that work with the body's existing pathways rather than synthetic alternatives.

Holistic Health Seekers: Individuals taking comprehensive approaches to wellness who want to address neurochemical aspects alongside lifestyle modifications.

Serotonin Support Interested: Those who've learned about serotonin's roles in mood, sleep, and appetite and want to support healthy levels*.

Tryptophan Alternative: People who've tried L-tryptophan with limited success and want to try the more direct precursor 5-HTP.

Not Candidates for Prescription: Individuals with subclinical concerns that don't meet criteria for prescription medications but still affect quality of life.

Important: Those with diagnosed mood disorders, sleep disorders, or other medical conditions should work with healthcare providers rather than relying solely on supplements.

Understanding Key Ingredients

5-Hydroxytryptophan (5-HTP)

5-HTP is an amino acid that serves as an intermediate in the biosynthesis of serotonin from L-tryptophan. When you consume 5-HTP, it crosses the blood-brain barrier and is converted to serotonin* through a one-step process involving the enzyme aromatic L-amino acid decarboxylase.

Research support for 5-HTP is substantial. A review published in Alternative Medicine Review (2008) examined clinical trials and found evidence supporting 5-HTP's potential to help with mood wellness*. Studies have examined various populations and dosages, generally finding that 50-300mg daily may provide benefits* for various individuals.

Griffonia simplicifolia is a woody climbing shrub native to West and Central Africa. Its seeds contain exceptionally high concentrations of 5-HTP (up to 20% by weight), making them the primary commercial source for 5-HTP supplements. The plant-derived origin provides naturally-occurring 5-HTP in a form the body recognizes*.

The mechanism is straightforward: 5-HTP → Serotonin → (at night) Melatonin. By providing the direct precursor, 5-HTP supplementation bypasses the rate-limiting steps* that can restrict serotonin production when starting from dietary protein alone.

Calcium

While often overlooked in discussions of mood supplements, calcium plays important roles in nervous system function* including neurotransmitter release* and nerve signal transmission*. The inclusion in this formula provides additional nutritional support for overall neurological wellness*.

Scientific References

Research on 5-HTP:

1. 5-HTP and Mood:
   • Birdsall TC. "5-Hydroxytryptophan: a clinically-effective serotonin precursor." Alternative Medicine Review. 1998;3(4):271-280.
   • https://pubmed.ncbi.nlm.nih.gov/9727088/
2. 5-HTP Overview:
   • Turner EH, et al. "Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan." Pharmacology & Therapeutics. 2006;109(3):325-338.
   • https://pubmed.ncbi.nlm.nih.gov/16023217/
3. 5-HTP and Sleep:
   • Wyatt RJ, et al. "Effects of 5-hydroxytryptophan on the sleep of normal human subjects." Electroencephalography and Clinical Neurophysiology. 1971;30(6):505-509.
   • https://pubmed.ncbi.nlm.nih.gov/4106495/
4. Serotonin and Appetite:
   • Halford JC, Blundell JE. "Separate systems for serotonin and leptin in appetite control." Annals of Medicine. 2000;32(3):222-232.
   • https://pubmed.ncbi.nlm.nih.gov/10821329/

Note: These references are for educational purposes. Individual results vary. This product is not intended to treat disease.

Important Disclaimer

FDA/FTC Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Classification: ShantiMoon 5-HTP is a dietary supplement featuring 5-Hydroxytryptophan for supporting serotonin synthesis* and emotional wellness*. It is not a drug, pharmaceutical treatment, or medical therapy.

Not Medical Treatment: This product does not treat, cure, or prevent mood disorders, sleep disorders, occasional stress disorders, or any disease. It supports general wellness* through providing a natural serotonin precursor. For diagnosed mental health conditions, sleep disorders, or other medical concerns, seek appropriate professional care.

Individual Results Vary: Responses to 5-HTP vary significantly based on individual factors including baseline serotonin status, genetics, diet, lifestyle, concurrent health conditions, medications, and consistency of use. The information provided is for educational purposes and should not be considered medical advice.

Critical Drug Interaction Warning: Never combine 5-HTP with antidepressants, anti-occasional stress medications, or other serotonergic drugs without explicit healthcare provider approval. Dangerous serotonin syndrome can result from this combination—a potentially life-threatening condition.

Consult Healthcare Professionals: Always consult with a qualified healthcare provider before starting 5-HTP supplementation, especially if you:

• Take any medications (particularly psychiatric medications)
• Have diagnosed mood disorders, sleep disorders, or other mental health conditions
• Have any medical conditions
• Are pregnant or nursing
• Are under 18 years of age
• Are scheduled for surgery (discontinue 2 weeks prior)

Not a Substitute for Professional Care: If you have diagnosed Emotional well-being, occasional stress disorder, sleep disorder, or other medical conditions, this supplement does not replace proper medical treatment. Use only under healthcare provider guidance as part of comprehensive care plans.

Quality Information: While manufactured following GMP standards in the USA, statements about this product have not been evaluated by the FDA. Use only as directed.

Complete Ingredient Profile: Understanding What Makes AgniLean Effective*

Primary Active Ingredients

Medium-Chain Triglycerides (MCT) Oil

MCT Oil is a unique type of fat derived from coconut oil or palm kernel oil that contains medium-chain fatty acids, typically with 6-12 carbon atoms. Unlike long-chain triglycerides found in most dietary fats, MCTs are absorbed more rapidly and may be preferentially used for energy rather than storage.* Research has explored MCT oil's potential role in supporting thermogenesis—the body's natural heat production process—and its effects on energy expenditure.* When incorporated into a balanced diet, MCT oil may help support satiety and provide a readily available energy source for both physical and mental activities.*

Studies have investigated MCT oil's potential benefits:

• A study published in the American Journal of Clinical Nutrition examined MCT oil's effects on energy expenditure and satiety
• Research in Weight management Research explored the potential role of MCTs in supporting body composition when combined with lifestyle modifications

L-Carnitine (as L-Carnitine Tartrate)

L-Carnitine is a naturally occurring amino acid derivative that plays an essential role in energy metabolism. Its primary function is transporting long-chain fatty acids across the mitochondrial membrane, where they undergo beta-oxidation to produce ATP—the energy currency of cells.* L-Carnitine may help support energy production, particularly during exercise and physical activity, and has been studied for its potential role in supporting athletic performance and recovery.*

The tartrate form of L-Carnitine is known for its high bioavailability and rapid absorption, making it particularly suitable for individuals seeking to support their exercise performance and recovery processes.* By helping ensure efficient fatty acid transport, L-Carnitine may support your body's ability to utilize fat as an energy source during both rest and activity.*

Research supporting L-Carnitine includes:

• Studies published in The Journal of Physiology examining L-Carnitine's role in muscle metabolism
• Research in Metabolism investigating L-Carnitine supplementation and exercise performance

Choline (as Choline Bitartrate)

Choline is an essential nutrient that supports several critical physiological functions, including cell membrane structure, neurotransmitter synthesis, and lipid metabolism.* In the liver, choline is crucial for the synthesis of phosphatidylcholine, a major component of very-low-density lipoproteins (VLDL), which help transport fats from the liver to other parts of the body.* Adequate choline intake may help support healthy liver function and the body's natural fat metabolism processes.*

Choline also serves as a precursor for acetylcholine, a neurotransmitter involved in memory, mood, and muscle control, making it important for both cognitive and physical performance.* The bitartrate form provides excellent bioavailability and is well-tolerated by most individuals.*

Scientific literature on choline includes:

• Reviews in Nutrients discussing choline's essential role in human health
• Research published in The Journal of Nutrition on choline and lipid metabolism

Chromium (as Chromium Polynicotinate)

Chromium is an essential trace mineral that plays a vital role in macronutrient metabolism, particularly the metabolism of carbohydrates and fats.* Chromium may help support healthy insulin function, which is important for maintaining normal blood sugar metabolism within healthy ranges.* By supporting insulin sensitivity, chromium may contribute to more efficient nutrient utilization and energy metabolism.*

The polynicotinate form of chromium combines chromium with niacin (vitamin B3), which may enhance absorption and bioavailability compared to other chromium forms.* This makes it particularly effective for individuals seeking to support their metabolic health and maintain healthy blood sugar levels as part of an overall wellness program.*

Research on chromium includes:

• Studies in Healthy glucose metabolism Technology & Therapeutics examining chromium's role in glucose metabolism
• Reviews in Journal of Trace Elements in Medicine and Biology on chromium supplementation

Vitamin C (as Ascorbic Acid)

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin with numerous essential functions in the human body. Beyond its well-known role as an antioxidant, vitamin C contributes to normal energy-yielding metabolism and helps reduce tiredness and fatigue.* It is also essential for collagen synthesis, immune function, and the absorption of non-heme iron from plant-based foods.*

In the context of metabolic support, vitamin C may help protect cells from oxidative stress that can occur during intense physical activity or metabolic processes.* Its role in supporting mitochondrial function and energy production makes it a valuable component of any comprehensive metabolic support formula.*

Vitamin B6 (as Pyridoxine HCL)

Vitamin B6 is a water-soluble vitamin that serves as a cofactor for over 100 enzymatic reactions in the body, many of which are involved in protein metabolism, neurotransmitter synthesis, and energy production.* Like vitamin C, vitamin B6 contributes to normal energy-yielding metabolism and helps reduce tiredness and fatigue.* It also plays a role in the metabolism of amino acids, glycogen, and lipids, making it essential for individuals with active lifestyles.*

Vitamin B6 may also support the synthesis of neurotransmitters such as serotonin and dopamine, which can influence mood, motivation, and cognitive function—all important factors when pursuing wellness goals.* The hydrochloride form (Pyridoxine HCL) is well-absorbed and commonly used in dietary supplements.*

Essential Fatty Acid Complex

Conjugated Linoleic Acid (CLA)

CLA is a group of positional and geometric isomers of linoleic acid, an omega-6 fatty acid. CLA has been extensively studied for its potential role in supporting healthy body composition when combined with diet and exercise.* Research has explored CLA's potential mechanisms, including its possible effects on fat metabolism, lean body mass maintenance, and overall metabolic health.*

Studies on CLA include:

• Research published in The American Journal of Clinical Nutrition examining CLA supplementation and body composition
• Meta-analyses in Nutrition Reviews evaluating CLA's effects in conjunction with lifestyle modifications

Gamma-Linolenic Acid (GLA)

GLA is an omega-6 fatty acid that the body can produce from linoleic acid, though direct supplementation may provide additional benefits.* GLA serves as a precursor to certain prostaglandins, which are hormone-like substances involved in various physiological processes including inflammation modulation and metabolic regulation.* Some research suggests that GLA supplementation may support healthy inflammatory responses and metabolic function when part of a comprehensive wellness program.*

Botanical and Traditional Ingredient Complex

Garcinia Cambogia Fruit Extract (50% Hydroxycitric Acid)

Garcinia cambogia is a tropical fruit native to Southeast Asia that has been used in traditional culinary and wellness practices for centuries. The active compound, hydroxycitric acid (HCA), has been studied for its potential effects on metabolic processes.* Research has explored HCA's possible role in supporting appetite regulation and carbohydrate metabolism, though results have been mixed and more research is needed.*

Our formula provides Garcinia cambogia extract standardized to 50% hydroxycitric acid to ensure consistency and potency in every serving.*

Gymnema Sylvestre Leaf Extract (25% Extract)

Gymnema sylvestre is a woody climbing plant native to India and Africa that has been used in traditional Ayurvedic practices for thousands of years. The plant's name in Hindi, "gurmar," literally means "sugar destroyer," reflecting its traditional use in supporting healthy blood sugar metabolism.* Research has investigated gymnema's potential mechanisms, including its possible effects on sugar absorption and insulin function within normal ranges.*

The 25% standardized extract ensures you receive a consistent and meaningful dose of gymnema's active compounds, particularly gymnemic acids, which are believed to be responsible for many of its potential benefits.*

Studies on Gymnema sylvestre include:

• Research in Journal of Ethnopharmacology on gymnema's traditional uses and potential mechanisms
• Studies published in Phytotherapy Research examining gymnema supplementation

Bladderwrack Thallus Powder

Bladderwrack (Fucus vesiculosus) is a type of brown seaweed rich in iodine, fucoidan, and other bioactive compounds. Iodine is essential for healthy thyroid function, and the thyroid gland plays a central role in regulating metabolism.* While the body only needs small amounts of iodine, adequate intake is important for maintaining normal thyroid hormone production and, consequently, normal metabolic function.*

Bladderwrack has been traditionally used in various cultures to support metabolic health and provide nutritional support from the sea.* It also contains other trace minerals and polyphenolic compounds that may contribute to overall wellness.*

Turmeric Root Extract (95% Curcuminoids)

Turmeric (Curcuma longa) is a golden-yellow spice that has been used in traditional Indian and Chinese wellness practices for thousands of years. The active compounds in turmeric, called curcuminoids (primarily curcumin), have been extensively studied for their antioxidant properties and potential role in supporting healthy inflammatory responses.*

While turmeric's primary benefits relate to antioxidant support and inflammatory modulation, these properties may indirectly support metabolic health by promoting overall cellular wellness and helping protect against oxidative stress.* Our formula provides turmeric extract standardized to 95% curcuminoids, ensuring high potency and consistency.*

Research on turmeric and curcumin is extensive:

• Reviews in Foods examining curcumin's bioavailability and potential health benefits
• Studies in Nutrition Reviews on curcumin's antioxidant and anti-inflammatory properties

Coenzyme Q10 (CoQ10)

Coenzyme Q10 is a naturally occurring compound found in every cell of the human body, with particularly high concentrations in organs with high energy demands such as the heart, liver, and kidneys. CoQ10 plays two essential roles: it is critical for ATP production within the mitochondria, and it functions as a powerful antioxidant, protecting cells from oxidative damage.*

As we age, our body's natural production of CoQ10 may decline, making supplementation potentially beneficial for maintaining optimal energy production and cellular health.* In the context of metabolic support, CoQ10 may help ensure that your cells can efficiently produce the energy they need to function optimally.*

Studies on CoQ10 include:

• Research in Biofactors examining CoQ10's role in cellular energy production
• Reviews in Antioxidants discussing CoQ10's antioxidant properties

Inositol

Inositol is a carbocyclic sugar that plays important roles in cell signaling, particularly in insulin signal transduction. Research has explored inositol's potential role in supporting healthy insulin sensitivity and glucose metabolism.* Inositol also serves as a component of cell membranes and may support healthy lipid metabolism.*

Some studies have investigated specific forms of inositol (such as myo-inositol and D-chiro-inositol) for their potential benefits in supporting metabolic health, particularly in conjunction with lifestyle modifications.*

Proprietary Synergistic Blend

Our carefully crafted Proprietary Blend combines amino acids, digestive enzymes, and botanical extracts to provide comprehensive nutritional support:

L-Tyrosine

An amino acid that serves as a precursor for several important neurotransmitters and hormones, including dopamine, norepinephrine, and thyroid hormones.* L-tyrosine may help support cognitive function, stress response, and mental alertness, which can be particularly beneficial when pursuing wellness goals that require focus and motivation.*

L-Phenylalanine

An essential amino acid that the body cannot produce and must obtain from diet or supplementation. L-phenylalanine serves as a precursor to L-tyrosine and, subsequently, to various neurotransmitters.* It may help support mood, cognitive function, and overall mental well-being.*

L-Methionine

An essential sulfur-containing amino acid involved in numerous metabolic processes, including the synthesis of other amino acids, proteins, and various important compounds like glutathione (a major antioxidant).* Methionine also plays a role in liver health and detoxification processes.*

Spirulina Powder

A blue-green algae that is one of the most nutrient-dense foods on the planet, containing high-quality protein, B vitamins, iron, and numerous phytonutrients including phycocyanin.* Spirulina has been used as a food source for centuries and may provide comprehensive nutritional support and antioxidant protection.*

Bromelain

A mixture of proteolytic enzymes derived from pineapple that may help support protein digestion and nutrient absorption.* Bromelain has also been studied for its potential role in supporting healthy inflammatory responses and overall digestive comfort.*

Kelp 10:1 Extract

A concentrated extract from kelp seaweed, providing a rich source of iodine, minerals, and other sea-derived nutrients that may support thyroid function and overall metabolic health.*

Cinnamon Bark 10:1 Extract (Cinnamomum cassia)

A concentrated extract from cinnamon bark that has been traditionally used to support healthy blood sugar metabolism and digestive function.* Research has explored cinnamon's potential role in supporting insulin sensitivity and glucose metabolism within normal ranges.*

Additional Botanical Extracts

The proprietary blend also includes concentrated extracts of:

• Juniper Berry 4:1 Extract: Traditionally used to support urinary tract health and provide antioxidant support*
• Buchu Leaf 4:1 Extract: A South African botanical traditionally used to support urinary health*
• Uva Ursi Leaf (20% Extract): Contains arbutin and has been traditionally used in various wellness practices*
• Cranberry Fruit Concentrate: Well-known for supporting urinary tract health and providing antioxidant support*
• Grapefruit Fruit 4:1 Extract: A concentrated source of vitamin C and flavonoids*
• Psyllium Husk Powder: A source of soluble fiber that supports digestive health and regularity*
• Clove Bud Powder and Allspice: Traditional culinary spices that provide antioxidant support*

Complete Ingredient Profile

Active Ingredients Per 2-Capsule Serving:

Primary Active Compounds:

• Granular Berberine Hydrochloride Extract 97% (Bark): High-potency pharmaceutical-grade berberine extract standardized to contain 97% pure berberine hydrochloride. This concentrated form ensures consistent, reliable dosing of the active alkaloid. Derived from bark sources, this extract provides the bioactive compound responsible for berberine's metabolic and cardiovascular benefits. The 97% standardization ensures you receive therapeutic levels of berberine in each serving.

• Granular Berberine Hydrochloride Extract 8% (Bark/Root): Complementary berberine extract from both bark and root sources, standardized to 8% berberine hydrochloride. While lower in concentration, this extract provides a broader spectrum of naturally occurring alkaloids and supporting compounds that work synergistically with pure berberine. The dual-source approach (bark and root) ensures comprehensive phytonutrient support and may enhance overall bioavailability and effectiveness.

Supporting Ingredients:

• Cellulose (Vegetable Capsule): Plant-based capsule shell made from vegetable cellulose, suitable for vegetarians and vegans. Provides a clean, neutral delivery system without animal-derived gelatin or unnecessary additives.

• MCC (Microcrystalline Cellulose): Natural plant-derived filler that helps with capsule formation and ensures consistent ingredient distribution. Provides bulk to the capsule while being inert and non-reactive.

• L-Leucine: Essential branched-chain amino acid used as a natural flow agent in supplement manufacturing. Prevents ingredients from clumping and ensures consistent capsule filling. Also provides minor nutritional benefits as an essential amino acid.

• Olive Oil: High-quality oil included to support absorption of berberine and other fat-soluble compounds. Olive oil may enhance bioavailability and provides additional antioxidant benefits from its natural polyphenol content.

Key Benefits of This Formula:

• Supports Healthy Blood Sugar Balance: Helps maintain glucose levels already within normal range*
• Promotes Cardiovascular Health: Supports healthy cholesterol and heart function*
• Supports Metabolic Function: Activates AMPK for metabolic optimization*
• May Support Weight Management: Helps maintain healthy metabolism when combined with diet and exercise*
• Supports Gut Health: Promotes healthy microbiome balance*
• Provides Antioxidant Benefits: Helps protect cells from oxidative stress*
• Dual-Standardized Formula: Combines 97% and 8% extracts for comprehensive support*
• Vegetarian-Friendly: Uses vegetable capsules, suitable for most dietary preferences*

Combine with Lifestyle Support: Clearex works best as part of a comprehensive approach to digestive wellness. Support your gut health by also:

• Managing stress through relaxation techniques
• Getting adequate sleep (7-9 hours nightly)
• Incorporating regular physical activity
• Minimizing processed foods and excess sugar
• Eating mindfully without rushing

Consider Timing with Other Supplements: If you take multiple supplements, spacing them out can optimize absorption. Many users take Clearex in the morning and reserve other supplements for later in the day.

Quality and Safety Information

Your safety and trust matter. Here's what you need to know about Clearex quality standards:

Manufacturing Standards: Clearex is produced in an Estonian facility that follows Good Manufacturing Practices (GMP). These standards ensure consistent production processes, quality control testing, and contamination prevention.

Testing Protocols: Each production batch undergoes testing to verify:

• Fulvic and humic acid content meets label specifications
• Absence of heavy metals (lead, mercury, cadmium, arsenic)
• Microbial contamination testing
• Botanical extract authentication

Shelf Life and Storage: When stored properly (sealed container, room temperature, away from moisture), Clearex maintains potency through the expiration date printed on the label. Do not use after this date.

Safety Considerations:

General Safety: Clearex is formulated from naturally occurring botanical compounds and is generally well-tolerated by healthy adults.* However, as with any dietary supplement, individual responses may vary.

Not a Medical Treatment: Clearex is a dietary supplement intended to support normal digestive function, not to diagnose, treat, cure, or prevent any disease.* It should not be used as a substitute for a varied, balanced diet or to replace prescribed medications.

Aloe Ferox Powder: Bitter Aloe Extract

Aloe ferox powder comes from a species of aloe native to South Africa, distinct from the more commonly known Aloe vera. This variety, sometimes called "bitter aloe" or "Cape aloe," has been used in traditional African wellness practices.*

Aloe ferox contains various plant compounds and has been traditionally used to support digestive processes.* The 18% standardization in this formula (Alion 18%) refers to the concentration of specific active compounds.*

While research on Aloe ferox specifically is more limited than on Aloe vera, studies have begun exploring its properties. A review in Phytochemistry Reviews examined the phytochemical composition of various aloe species including Aloe ferox and discussed their traditional applications.* (Reference: Grace OM, Simmonds MSJ, Smith GF, van Wyk AE. Therapeutic uses of Aloe L. (Asphodelaceae) in southern Africa. J Ethnopharmacol. 2008;119(3):604-614. https://pubmed.ncbi.nlm.nih.gov/18761071/)

Black Walnut Hulls Powder: Traditional Herbal Component

Black walnut hulls powder comes from the outer husk of black walnut (Juglans nigra) and has been used in various traditional herbal practices. The hulls contain tannins and other plant compounds that differ from the nutritional nut meat inside.*

This ingredient has historically been included in traditional cleansing formulas, though it's important to understand that these traditional uses don't constitute medical claims.* Black walnut hulls contribute to the botanical diversity of this comprehensive blend.*

Important allergen note: Black walnut is a tree nut, and individuals with tree nut allergies should avoid this product.

Ethnobotanical research has documented the traditional uses of black walnut. A review in Pharmacognosy Reviews examined various parts of the black walnut tree and their historical applications in traditional practices.* (Reference: Jahanban-Esfahlan A, Ostadrahimi A, Tabibiazar M, Amarowicz R. A Comprehensive Review on the Chemical Constituents and Functional Uses of Walnut (Juglans spp.) Husk. Int J Mol Sci. 2019;20(16):3920. https://pubmed.ncbi.nlm.nih.gov/31412640/)

How Cardeva Resveratrol Supports Your Wellness Goals

Powerful Antioxidant Protection for Cellular Health

At the heart of Cardeva Resveratrol's benefits is its potent antioxidant activity. Each capsule delivers 600mg of resveratrol complex standardized to contain 50% Trans-Resveratrol, the most bioavailable and researched form of this compound.*

Antioxidants work by donating electrons to free radicals, neutralizing free radicals and supporting the body's natural defense against oxidative stress. By helping maintain the balance between free radicals and antioxidants in your body, resveratrol may support:*

• Cellular membrane integrity and function*
• DNA protection from oxidative stress*
• Healthy cellular aging processes*
• Overall cellular vitality and resilience*

Supporting Cardiovascular Wellness from Multiple Angles

Your cardiovascular system works tirelessly to deliver oxygen and nutrients throughout your body. Resveratrol supplementation has been studied for its potential to support cardiovascular health through several mechanisms:*

• May help support healthy endothelial function (the inner lining of blood vessels)*
• Contributes to maintaining healthy circulation patterns*
• Supports the body's natural inflammatory response processes*
• May help support healthy lipid metabolism when combined with a heart-healthy diet*

Research suggests that the cardiovascular benefits of resveratrol may be related to its antioxidant properties and its potential influence on various cellular signaling pathways involved in cardiovascular function.*

Cognitive Function and Mental Clarity Support

Brain health is foundational to quality of life at every age. Resveratrol's support for the nervous system has been the subject of extensive research, with studies exploring its potential to:*

• Support healthy cognitive function and mental performance*
• Help maintain normal memory processes*
• Support the brain's natural defense mechanisms against oxidative stress*
• Contribute to healthy neuronal function and communication*

While more research is ongoing, preliminary studies suggest that resveratrol's ability to cross the blood-brain barrier allows it to exert antioxidant effects directly in brain tissue, potentially supporting cognitive wellness.*

Metabolic Health and Wellness Support

Maintaining healthy metabolic function is essential for energy production, weight management, and overall vitality. Resveratrol supplements have been researched for their potential role in supporting:*

• Healthy glucose metabolism when combined with a balanced diet*
• Normal energy production at the cellular level*
• General metabolic processes involved in nutrient utilization*
• Healthy body composition goals when paired with exercise and proper nutrition*

It's important to note that resveratrol is not a weight loss product on its own, but rather a supportive supplement that may contribute to metabolic wellness as part of a comprehensive healthy lifestyle approach.*