Matevara
Nexus Berberine HCL Supplement | 97% Berberine Hydrochloride Extract | Metabolic & Cardiovascular Support Capsules | 60 Count
$66.95 USD
Unit price perNexus Berberine HCL Supplement – Premium Berberine Hydrochloride for Metabolic & Cardiovascular Wellness
Discover the power of nature's most researched plant compound with Nexus Berberine HCL Supplement, a premium berberine hydrochloride supplement featuring high-potency 97% standardized extract to support your metabolic health, cardiovascular wellness, and overall vitality. This berberine capsules formula delivers concentrated Berberine Hydrochloride Extract derived from traditional botanicals, providing convenient daily support for blood sugar balance, healthy cholesterol levels, and metabolic function.*
Berberine is a bioactive compound extracted from several plants including barberry, goldenseal, and tree turmeric, with a history spanning thousands of years in Traditional Chinese Medicine and Ayurvedic practices. Modern scientific research has validated many of berberine's traditional uses, with hundreds of studies demonstrating its potential to support metabolic health, cardiovascular function, and overall wellness. Nexus Berberine harnesses this ancient wisdom with modern extraction technology to deliver pharmaceutical-grade purity in an easy-to-use capsule format.*
This metabolic support supplement features dual-standardized berberine extracts—97% and 8% Berberine Hydrochloride—providing a comprehensive spectrum of beneficial compounds from both bark and root sources. Unlike single-source berberine products, this combination approach ensures you receive the full range of naturally occurring alkaloids and supportive phytonutrients that work synergistically for optimal benefits. Whether you're seeking to support healthy glucose metabolism, maintain cardiovascular wellness, or promote balanced weight management as part of a healthy lifestyle, this berberine HCL formula provides research-backed nutritional support.*
Manufactured in the USA with quality ingredients and convenient vegetable capsules, Nexus Berberine represents a scientifically-informed approach to metabolic wellness—helping you maintain balance, support heart health, and optimize your body's natural metabolic processes as part of your comprehensive wellness routine.*
Top 4 Pain Points & How Nexus Berberine Supports You
Pain Point #1: Blood Sugar Balance & Metabolic Health Concerns
Many people struggle with maintaining healthy blood sugar levels already within normal range, particularly as they age, experience stress, or face dietary challenges. Irregular blood sugar patterns can affect energy levels, mood, cravings, and overall wellness. Supporting the body's natural glucose metabolism becomes increasingly important for long-term health, yet finding effective nutritional support can be challenging.
How Nexus Supports You: Berberine is one of the most extensively researched natural compounds for supporting healthy glucose metabolism. Multiple clinical studies have demonstrated berberine's ability to help maintain blood sugar levels already within normal range through several mechanisms. Berberine activates AMPK (adenosine monophosphate-activated protein kinase), often called the "metabolic master switch," which plays a crucial role in regulating glucose and lipid metabolism. By activating AMPK, berberine helps support the body's natural insulin sensitivity, promotes healthy glucose uptake by cells, and supports the liver's ability to regulate glucose production. Our high-potency 97% berberine extract provides concentrated support for these metabolic pathways, helping your body maintain balanced blood sugar levels as part of a healthy diet and lifestyle. With consistent use alongside proper nutrition and exercise, this supplement supports your metabolic health and helps you maintain steady energy throughout the day.*
Pain Point #2: Cardiovascular Health & Cholesterol Management
Heart health is a major concern for millions of people, particularly those with family history or age-related cardiovascular considerations. Maintaining healthy cholesterol levels—including LDL, HDL, and triglycerides—is crucial for cardiovascular wellness. Many people seek natural ways to support heart health and maintain cholesterol levels already within normal range without immediately resorting to pharmaceutical interventions.
How Nexus Supports You: Research has shown berberine's impressive potential for supporting cardiovascular health through multiple pathways. Berberine helps support healthy cholesterol levels already within normal range by influencing cholesterol metabolism in the liver and promoting healthy lipid profiles. Studies indicate berberine may help maintain healthy LDL cholesterol, support optimal HDL cholesterol, and promote balanced triglyceride levels. Additionally, berberine supports healthy endothelial function (the inner lining of blood vessels), which is crucial for cardiovascular health. The compound's antioxidant properties help protect against oxidative stress that can affect cardiovascular tissues. By activating AMPK, berberine also supports healthy fat metabolism and may help reduce fat accumulation in the liver. Our cardiovascular support berberine formula provides comprehensive nutritional support for heart health, helping you maintain healthy cholesterol balance and supporting your cardiovascular system's optimal function as part of a heart-healthy lifestyle including proper diet and regular physical activity.*
Pain Point #3: Weight Management Challenges & Metabolic Rate
Despite efforts with diet and exercise, many people struggle with weight management, metabolic slowdown, and difficulty maintaining healthy body composition. Factors including age, hormones, stress, sleep quality, and metabolic efficiency all impact weight management success. Supporting the body's natural metabolic rate and fat-burning capacity can make a significant difference in weight management efforts.
How Nexus Supports You: While not a magic weight-loss pill, berberine has been studied for its potential to support healthy weight management when combined with proper diet and exercise. Through AMPK activation, berberine helps support the body's fat-burning processes and may help promote healthy metabolic rate. Research suggests berberine may support healthy body composition by influencing how the body stores and utilizes fat, supporting healthy adipose tissue function, and promoting balanced energy metabolism. Berberine may also help support healthy appetite regulation and promote feelings of satiety when combined with balanced meals. Additionally, by supporting healthy blood sugar balance, berberine helps reduce energy crashes and cravings that can derail healthy eating plans. Our metabolic wellness berberine supplement provides nutritional support for your weight management journey, helping optimize your body's natural fat metabolism when used as part of a comprehensive program including calorie-conscious nutrition and regular physical activity. Remember: sustainable weight management requires lifestyle changes—berberine is a supportive tool, not a replacement for healthy habits.*
Pain Point #4: Gut Health & Microbiome Balance
Digestive health and microbiome balance are increasingly recognized as foundational to overall wellness, affecting everything from immune function to mood, metabolism, and inflammation. Many people experience gut imbalances, occasional digestive discomfort, or seek to support their intestinal health. The gut microbiome plays crucial roles in nutrient absorption, immune function, and even metabolic health.
How Nexus Supports You: Emerging research highlights berberine's potential to support healthy gut microbiome balance. Berberine exhibits antimicrobial properties that may help maintain healthy bacterial balance in the digestive tract, supporting beneficial bacteria while helping control overgrowth of less desirable microorganisms. Studies suggest berberine may help support the integrity of the intestinal barrier, promote healthy gut lining function, and support balanced inflammatory responses in the digestive tract. The gut-metabolic connection means that supporting gut health through berberine may also contribute to better metabolic outcomes, as the microbiome influences glucose metabolism, fat storage, and appetite regulation. Additionally, berberine's support for healthy bile flow contributes to optimal fat digestion and nutrient absorption. By supporting a balanced gut environment, our berberine supplement contributes to foundational wellness that extends beyond just digestive health, influencing overall metabolic function, immune support, and vitality.*
Complete Ingredient Profile
Active Ingredients Per 2-Capsule Serving:
Primary Active Compounds:
- Granular Berberine Hydrochloride Extract 97% (Bark): High-potency pharmaceutical-grade berberine extract standardized to contain 97% pure berberine hydrochloride. This concentrated form ensures consistent, reliable dosing of the active alkaloid. Derived from bark sources, this extract provides the bioactive compound responsible for berberine's metabolic and cardiovascular benefits. The 97% standardization ensures you receive therapeutic levels of berberine in each serving.
- Granular Berberine Hydrochloride Extract 8% (Bark/Root): Complementary berberine extract from both bark and root sources, standardized to 8% berberine hydrochloride. While lower in concentration, this extract provides a broader spectrum of naturally occurring alkaloids and supporting compounds that work synergistically with pure berberine. The dual-source approach (bark and root) ensures comprehensive phytonutrient support and may enhance overall bioavailability and effectiveness.
Supporting Ingredients:
- Cellulose (Vegetable Capsule): Plant-based capsule shell made from vegetable cellulose, suitable for vegetarians and vegans. Provides a clean, neutral delivery system without animal-derived gelatin or unnecessary additives.
- MCC (Microcrystalline Cellulose): Natural plant-derived filler that helps with capsule formation and ensures consistent ingredient distribution. Provides bulk to the capsule while being inert and non-reactive.
- L-Leucine: Essential branched-chain amino acid used as a natural flow agent in supplement manufacturing. Prevents ingredients from clumping and ensures consistent capsule filling. Also provides minor nutritional benefits as an essential amino acid.
- Olive Oil: High-quality oil included to support absorption of berberine and other fat-soluble compounds. Olive oil may enhance bioavailability and provides additional antioxidant benefits from its natural polyphenol content.
Key Benefits of This Formula:
- Supports Healthy Blood Sugar Balance: Helps maintain glucose levels already within normal range*
- Promotes Cardiovascular Health: Supports healthy cholesterol and heart function*
- Supports Metabolic Function: Activates AMPK for metabolic optimization*
- May Support Weight Management: Helps maintain healthy metabolism when combined with diet and exercise*
- Supports Gut Health: Promotes healthy microbiome balance*
- Provides Antioxidant Benefits: Helps protect cells from oxidative stress*
- Dual-Standardized Formula: Combines 97% and 8% extracts for comprehensive support*
- Vegetarian-Friendly: Uses vegetable capsules, suitable for most dietary preferences*
Why Choose Nexus Berberine?
Pharmaceutical-Grade 97% Standardization
Features high-potency 97% berberine hydrochloride extract—among the highest standardization available—ensuring you receive therapeutic levels of the active compound in every serving.
Dual-Extract Synergy
Unique combination of 97% pure extract with 8% broad-spectrum extract from bark and root sources provides both concentrated berberine and supporting alkaloids for comprehensive benefits.
Research-Backed Compound
Berberine is one of the most extensively studied natural supplements with hundreds of clinical trials supporting its metabolic and cardiovascular benefits—not just traditional use but modern scientific validation.
AMPK Activation
Supports activation of AMPK, the "metabolic master switch" that regulates glucose and fat metabolism, energy production, and cellular health—a key mechanism behind berberine's diverse benefits.
Cardiovascular Support
Provides multi-faceted support for heart health including healthy cholesterol levels, endothelial function, and cardiovascular tissue protection.
Vegetarian-Friendly Formula
Uses plant-based vegetable capsules rather than gelatin, making it suitable for vegetarians, vegans, and those avoiding animal products.
Enhanced Absorption
Includes olive oil to support berberine absorption and bioavailability, helping ensure your body can effectively utilize this beneficial compound.
Made in USA
Manufactured in the United States under quality control standards for consistency and purity.
Convenient Two-Capsule Serving
Simple once-daily dosing (two capsules) makes it easy to incorporate into your wellness routine.
How to Use for Optimal Results
Recommended Dosage: As a dietary supplement, adults take two (2) capsules daily.
Optimal Timing: For best results, take with 6-8 oz (177-236ml) of water or as directed by your healthcare professional. Many users prefer taking berberine with meals to support post-meal glucose metabolism and enhance absorption.
Consistency Matters:
- Take at the same time each day to establish routine
- Berberine works gradually—commit to at least 8-12 weeks of consistent use
- Benefits build over time as berberine supports metabolic pathways
- Most users notice improvements in energy and well-being within 2-4 weeks, with optimal metabolic benefits developing over 2-3 months
Hydration: Always take with adequate water (6-8oz minimum) to support proper absorption and minimize potential digestive sensitivity.
Duration: Safe for long-term daily use when taken as directed. Many users incorporate berberine as an ongoing part of their wellness routine.
Usage Tips for Maximum Benefits
- Take with Meals: Berberine is best absorbed when taken with food. Taking with meals also supports post-meal glucose metabolism and may minimize any mild digestive effects.
- Divide Dosing if Sensitive: If you experience digestive sensitivity, consider splitting your dose—take one capsule with breakfast and one with dinner rather than both at once.
- Stay Consistent: Set a daily reminder or keep berberine with your meals as a visual cue. Consistency is more important than perfect timing.
- Support with Lifestyle: Maximize berberine's benefits by maintaining a balanced diet rich in whole foods, engaging in regular physical activity, managing stress, and getting adequate sleep.
- Monitor Your Progress: If using berberine to support specific health metrics (blood sugar, cholesterol), work with your healthcare provider to monitor levels and track improvements over time.
- Pair with Probiotics: Since berberine affects gut microbiome, consider taking a quality probiotic supplement (at a different time of day) to maintain healthy bacterial balance.
- Stay Hydrated: Drink plenty of water throughout the day (at least 8 glasses) to support metabolism and overall wellness.
- Be Patient: Natural supplements work gradually. Allow 8-12 weeks to evaluate full benefits rather than expecting immediate dramatic changes.
- Consult Healthcare Provider: If you have diabetes, take medications (especially metformin or other glucose-lowering drugs), or have medical conditions, discuss berberine use with your healthcare provider before starting.
- Avoid Grapefruit: Grapefruit can interfere with berberine metabolism. Avoid grapefruit and grapefruit juice while taking berberine.
Who Will Benefit from Nexus Berberine?
Our premium berberine supplement is ideal for:
- Individuals Supporting Metabolic Health seeking natural blood sugar support
- Those Monitoring Cholesterol Levels wanting cardiovascular wellness support
- People Managing Weight as part of diet and exercise programs
- Adults Over 40 experiencing age-related metabolic changes
- Those with Family History of metabolic or cardiovascular concerns
- Prediabetic Individuals working to maintain healthy glucose levels (with medical supervision)
- People Seeking AMPK Activation for metabolic optimization
- Gut Health Enthusiasts wanting microbiome balance support
- Fitness Enthusiasts seeking metabolic efficiency and body composition support
- Health-Conscious Adults taking proactive approach to wellness
- Those Reducing Sugar Intake wanting additional metabolic support
- Individuals with Metabolic Syndrome Risk Factors (with healthcare guidance)
- People Wanting Research-Backed Supplements preferring scientifically validated compounds
For adult use only. Not suitable for children under 18, pregnant women, or nursing mothers. Those with medical conditions or taking medications should consult healthcare providers before use.
Understanding Key Ingredients
Berberine Hydrochloride
Berberine is a bioactive alkaloid compound extracted from several plants including Berberis species (barberry), Coptis chinensis (goldthread), Hydrastis canadensis (goldenseal), and Berberis aristata (tree turmeric). It has been used for thousands of years in Traditional Chinese Medicine and Ayurvedic medicine for various health purposes. The distinctive yellow color of berberine-containing plants made them valuable as natural dyes historically.
Modern scientific research has extensively validated berberine's health benefits, with over 4,000 published studies investigating its mechanisms and effects. Berberine's primary mechanism involves activating AMPK (AMP-activated protein kinase), an enzyme that acts as a "metabolic master switch" regulating energy metabolism, glucose uptake, fat burning, and cellular health. This AMPK activation is similar to the mechanism of metformin, a common diabetes medication, though berberine is a natural compound.
Research demonstrates berberine's multiple mechanisms for supporting metabolic health:
- Improves insulin sensitivity at the cellular level
- Decreases glucose production in the liver
- Increases glycolysis (breakdown of glucose inside cells)
- Slows carbohydrate breakdown in the gut
- Supports healthy gut microbiome composition
- Activates brown adipose tissue for fat burning
- Reduces inflammation markers
- Provides antioxidant protection
For cardiovascular health, studies show berberine supports healthy cholesterol by:
- Upregulating LDL receptors in the liver
- Inhibiting PCSK9, a protein that degrades LDL receptors
- Reducing cholesterol synthesis
- Supporting healthy triglyceride metabolism
- Protecting endothelial function
Berberine's bioavailability is relatively low (less than 5% absorption), which is why high-potency extracts and supporting ingredients like olive oil are important for effectiveness. Despite low bioavailability, berberine still demonstrates significant benefits, likely due to its effects on the gut microbiome and local intestinal absorption.
Dual Standardization Approach
Our formula uniquely combines two berberine extracts:
97% Extract: Provides high-concentration pure berberine hydrochloride for therapeutic dosing. This pharmaceutical-grade standardization ensures consistent levels of the active compound responsible for metabolic benefits.
8% Extract: Offers a broader spectrum extract containing berberine plus supporting alkaloids (including palmatine, jatrorrhizine, and others) and phytonutrients naturally present in bark and root sources. This "whole plant approach" may enhance effectiveness through synergistic actions.
This combination provides both the proven benefits of concentrated berberine and the potential advantages of full-spectrum plant compounds working together as nature intended.
Quality & Safety Information
Made in USA: Manufactured in the United States under quality control standards.
For Adult Use Only: This supplement is formulated for adults and is not intended for children under 18 years of age.
Important Safety Information:
- Do not exceed recommended dose of 2 capsules daily
- Pregnant or nursing mothers should NOT use this product
- Children under 18 should not use this product
- Individuals with known medical conditions must consult physician before use
- Those taking medications should consult healthcare provider—berberine may interact with various drugs
- Keep out of reach of children
- Do not use if safety seal is damaged or missing
- Store in a cool, dry place away from direct sunlight
Critical Medical Considerations:
- Diabetes/Blood Sugar Medications: Berberine may lower blood sugar. If taking diabetes medications (metformin, insulin, sulfonylureas, etc.), consult your doctor before use as dosage adjustments may be needed. Monitor blood sugar closely.
- Cholesterol Medications: May interact with statins and other cholesterol drugs. Consult healthcare provider.
- Blood Pressure Medications: Berberine may affect blood pressure. Consult healthcare provider if taking antihypertensive medications.
- Anticoagulants: May affect blood clotting. Consult healthcare provider if taking warfarin or other blood thinners.
- Immunosuppressants: Berberine may interact with cyclosporine and other immunosuppressive drugs.
- Cytochrome P450 Substrates: Berberine inhibits CYP3A4 and other enzymes, potentially affecting metabolism of many medications.
Potential Side Effects: Generally well-tolerated, but some individuals may experience:
- Mild digestive upset, gas, or cramping (usually temporary)
- Diarrhea or constipation (taking with food helps)
- Rarely: headache or low blood sugar if taking with other glucose-lowering compounds
Contraindications:
- Pregnancy and breastfeeding
- Children
- Severe liver or kidney disease
- Upcoming surgery (discontinue 2 weeks prior)
- Low blood pressure (hypotension)
Product Specifications
- Capsule Count: 60 capsules per bottle
- Servings Per Container: 30 servings
- Serving Size: 2 capsules
- Gross Weight: 0.2 lb / 90g
- Form: Vegetable capsules
- Capsule Type: Vegetarian cellulose
- Manufacturing Country: USA
Scientific References
While specific product claims are not made, the following research supports the metabolic and cardiovascular benefits of berberine:
- Berberine and Blood Sugar: Yin J, Xing H, Ye J. "Efficacy of berberine in patients with type 2 diabetes mellitus." Metabolism. 2008;57(5):712-717. https://pubmed.ncbi.nlm.nih.gov/18442638/
- Berberine and Cholesterol: Kong W, et al. "Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins." Nature Medicine. 2004;10(12):1344-1351. https://pubmed.ncbi.nlm.nih.gov/15531889/
- Berberine AMPK Activation: Lee YS, et al. "Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states." Diabetes. 2006;55(8):2256-2264. https://pubmed.ncbi.nlm.nih.gov/16873688/
- Berberine and Weight: Zhang Y, et al. "Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine." Journal of Clinical Endocrinology & Metabolism. 2008;93(7):2559-2565. https://pubmed.ncbi.nlm.nih.gov/18397984/
- Berberine and Gut Microbiome: Zhang X, et al. "Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats." PLoS One. 2012;7(8):e42529. https://pubmed.ncbi.nlm.nih.gov/22880019/
- Comprehensive Berberine Review: Imenshahidi M, Hosseinzadeh H. "Berberine and barberry (Berberis vulgaris): A clinical review." Phytotherapy Research. 2019;33(3):504-523. https://pubmed.ncbi.nlm.nih.gov/30556613/
Note: These references are provided for educational purposes regarding berberine research. Individual results may vary.
Frequently Asked Questions
REQUIRED FDA/FTC DISCLAIMER:
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for educational purposes only and is not intended as a substitute for advice from your physician or other healthcare professional. You should not use this information for self-diagnosis or for treating a health problem or disease. If you have or suspect you have a health problem, consult your healthcare provider. Individual results may vary. Always consult with a qualified healthcare professional before starting any diet, exercise, or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. This product may interact with medications including but not limited to diabetes medications, blood pressure medications, cholesterol medications, blood thinners, and others. Berberine may lower blood sugar—those with diabetes or taking glucose-lowering medications must consult their healthcare provider before use and monitor blood sugar levels closely. Not for use by pregnant or nursing women, children under 18, or individuals with liver or kidney disease without medical supervision.
Important Safety & Usage Warning:
Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Keep out of reach of children. Store in a cool, dry place.
Disclaimer:*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for educational purposes only and is not intended as a substitute for advice from your physician or other healthcare professional. You should not use this information for self-diagnosis or for treating a health problem or disease. If you have or suspect you have a health problem, consult your healthcare provider. Individual results may vary. Always consult with a qualified healthcare professional before starting any diet, exercise, or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. This product may interact with medications including but not limited to diabetes medications, blood pressure medications, cholesterol medications, blood thinners, and others. Berberine may lower blood sugar—those with diabetes or taking glucose-lowering medications must consult their healthcare provider before use and monitor blood sugar levels closely. Not for use by pregnant or nursing women, children under 18, or individuals with liver or kidney disease without medical supervision.
Nexus Berberine HCL Supplement | 97% Berberine Hydrochloride Extract | Metabolic & Cardiovascular Support Capsules | 60 Count
$66.95 USD
Unit price perIn stock
Estimated delivery between December 14 and December 18.
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Ingredients
Additional Information
-
Manufacturer's country
USA
-
Product amount
60 capsules
-
Gross weight (lb/g)
0.2 lb / 90 g
-
Suggested use
-
As a dietary supplement, adults take two (2) capsules daily. For best results, take with 68 oz (177-236ml) of water or as directed by healthcare professional.
-
Warning
-
Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.
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Benefits of Nexus Berberine HCL Supplement | 97% Berberine Hydrochloride Extract | Metabolic & Cardiovascular Support Capsules | 60 Count
Discover the key benefits that make our product stand out
Support Healthy Blood Sugar
Enhance Metabolic Efficiency
Promote Weight Management
Support Cardiovascular Health
About Nexus Berberine HCL Supplement | 97% Berberine Hydrochloride Extract | Metabolic & Cardiovascular Support Capsules | 60 Count
Nexus Berberine HCL Supplement – Premium Berberine Hydrochloride for Metabolic & Cardiovascular Wellness
Discover the power of nature's most researched plant compound with Nexus Berberine HCL Supplement, a premium berberine hydrochloride supplement featuring high-potency 97% standardized extract to support your metabolic health, cardiovascular wellness, and overall vitality. This berberine capsules formula delivers concentrated Berberine Hydrochloride Extract derived from traditional botanicals, providing convenient daily support for blood sugar balance, healthy cholesterol levels, and metabolic function.*
Berberine is a bioactive compound extracted from several plants including barberry, goldenseal, and tree turmeric, with a history spanning thousands of years in Traditional Chinese Medicine and Ayurvedic practices. Modern scientific research has validated many of berberine's traditional uses, with hundreds of studies demonstrating its potential to support metabolic health, cardiovascular function, and overall wellness. Nexus Berberine harnesses this ancient wisdom with modern extraction technology to deliver pharmaceutical-grade purity in an easy-to-use capsule format.*
This metabolic support supplement features dual-standardized berberine extracts—97% and 8% Berberine Hydrochloride—providing a comprehensive spectrum of beneficial compounds from both bark and root sources. Unlike single-source berberine products, this combination approach ensures you receive the full range of naturally occurring alkaloids and supportive phytonutrients that work synergistically for optimal benefits. Whether you're seeking to support healthy glucose metabolism, maintain cardiovascular wellness, or promote balanced weight management as part of a healthy lifestyle, this berberine HCL formula provides research-backed nutritional support.*
Manufactured in the USA with quality ingredients and convenient vegetable capsules, Nexus Berberine represents a scientifically-informed approach to metabolic wellness—helping you maintain balance, support heart health, and optimize your body's natural metabolic processes as part of your comprehensive wellness routine.*
Top 4 Pain Points & How Nexus Berberine Supports You
Pain Point #1: Blood Sugar Balance & Metabolic Health Concerns
Many people struggle with maintaining healthy blood sugar levels already within normal range, particularly as they age, experience stress, or face dietary challenges. Irregular blood sugar patterns can affect energy levels, mood, cravings, and overall wellness. Supporting the body's natural glucose metabolism becomes increasingly important for long-term health, yet finding effective nutritional support can be challenging.
How Nexus Supports You: Berberine is one of the most extensively researched natural compounds for supporting healthy glucose metabolism. Multiple clinical studies have demonstrated berberine's ability to help maintain blood sugar levels already within normal range through several mechanisms. Berberine activates AMPK (adenosine monophosphate-activated protein kinase), often called the "metabolic master switch," which plays a crucial role in regulating glucose and lipid metabolism. By activating AMPK, berberine helps support the body's natural insulin sensitivity, promotes healthy glucose uptake by cells, and supports the liver's ability to regulate glucose production. Our high-potency 97% berberine extract provides concentrated support for these metabolic pathways, helping your body maintain balanced blood sugar levels as part of a healthy diet and lifestyle. With consistent use alongside proper nutrition and exercise, this supplement supports your metabolic health and helps you maintain steady energy throughout the day.*
Pain Point #2: Cardiovascular Health & Cholesterol Management
Heart health is a major concern for millions of people, particularly those with family history or age-related cardiovascular considerations. Maintaining healthy cholesterol levels—including LDL, HDL, and triglycerides—is crucial for cardiovascular wellness. Many people seek natural ways to support heart health and maintain cholesterol levels already within normal range without immediately resorting to pharmaceutical interventions.
How Nexus Supports You: Research has shown berberine's impressive potential for supporting cardiovascular health through multiple pathways. Berberine helps support healthy cholesterol levels already within normal range by influencing cholesterol metabolism in the liver and promoting healthy lipid profiles. Studies indicate berberine may help maintain healthy LDL cholesterol, support optimal HDL cholesterol, and promote balanced triglyceride levels. Additionally, berberine supports healthy endothelial function (the inner lining of blood vessels), which is crucial for cardiovascular health. The compound's antioxidant properties help protect against oxidative stress that can affect cardiovascular tissues. By activating AMPK, berberine also supports healthy fat metabolism and may help reduce fat accumulation in the liver. Our cardiovascular support berberine formula provides comprehensive nutritional support for heart health, helping you maintain healthy cholesterol balance and supporting your cardiovascular system's optimal function as part of a heart-healthy lifestyle including proper diet and regular physical activity.*
Pain Point #3: Weight Management Challenges & Metabolic Rate
Despite efforts with diet and exercise, many people struggle with weight management, metabolic slowdown, and difficulty maintaining healthy body composition. Factors including age, hormones, stress, sleep quality, and metabolic efficiency all impact weight management success. Supporting the body's natural metabolic rate and fat-burning capacity can make a significant difference in weight management efforts.
How Nexus Supports You: While not a magic weight-loss pill, berberine has been studied for its potential to support healthy weight management when combined with proper diet and exercise. Through AMPK activation, berberine helps support the body's fat-burning processes and may help promote healthy metabolic rate. Research suggests berberine may support healthy body composition by influencing how the body stores and utilizes fat, supporting healthy adipose tissue function, and promoting balanced energy metabolism. Berberine may also help support healthy appetite regulation and promote feelings of satiety when combined with balanced meals. Additionally, by supporting healthy blood sugar balance, berberine helps reduce energy crashes and cravings that can derail healthy eating plans. Our metabolic wellness berberine supplement provides nutritional support for your weight management journey, helping optimize your body's natural fat metabolism when used as part of a comprehensive program including calorie-conscious nutrition and regular physical activity. Remember: sustainable weight management requires lifestyle changes—berberine is a supportive tool, not a replacement for healthy habits.*
Pain Point #4: Gut Health & Microbiome Balance
Digestive health and microbiome balance are increasingly recognized as foundational to overall wellness, affecting everything from immune function to mood, metabolism, and inflammation. Many people experience gut imbalances, occasional digestive discomfort, or seek to support their intestinal health. The gut microbiome plays crucial roles in nutrient absorption, immune function, and even metabolic health.
How Nexus Supports You: Emerging research highlights berberine's potential to support healthy gut microbiome balance. Berberine exhibits antimicrobial properties that may help maintain healthy bacterial balance in the digestive tract, supporting beneficial bacteria while helping control overgrowth of less desirable microorganisms. Studies suggest berberine may help support the integrity of the intestinal barrier, promote healthy gut lining function, and support balanced inflammatory responses in the digestive tract. The gut-metabolic connection means that supporting gut health through berberine may also contribute to better metabolic outcomes, as the microbiome influences glucose metabolism, fat storage, and appetite regulation. Additionally, berberine's support for healthy bile flow contributes to optimal fat digestion and nutrient absorption. By supporting a balanced gut environment, our berberine supplement contributes to foundational wellness that extends beyond just digestive health, influencing overall metabolic function, immune support, and vitality.*
Complete Ingredient Profile
Active Ingredients Per 2-Capsule Serving:
Primary Active Compounds:
- Granular Berberine Hydrochloride Extract 97% (Bark): High-potency pharmaceutical-grade berberine extract standardized to contain 97% pure berberine hydrochloride. This concentrated form ensures consistent, reliable dosing of the active alkaloid. Derived from bark sources, this extract provides the bioactive compound responsible for berberine's metabolic and cardiovascular benefits. The 97% standardization ensures you receive therapeutic levels of berberine in each serving.
- Granular Berberine Hydrochloride Extract 8% (Bark/Root): Complementary berberine extract from both bark and root sources, standardized to 8% berberine hydrochloride. While lower in concentration, this extract provides a broader spectrum of naturally occurring alkaloids and supporting compounds that work synergistically with pure berberine. The dual-source approach (bark and root) ensures comprehensive phytonutrient support and may enhance overall bioavailability and effectiveness.
Supporting Ingredients:
- Cellulose (Vegetable Capsule): Plant-based capsule shell made from vegetable cellulose, suitable for vegetarians and vegans. Provides a clean, neutral delivery system without animal-derived gelatin or unnecessary additives.
- MCC (Microcrystalline Cellulose): Natural plant-derived filler that helps with capsule formation and ensures consistent ingredient distribution. Provides bulk to the capsule while being inert and non-reactive.
- L-Leucine: Essential branched-chain amino acid used as a natural flow agent in supplement manufacturing. Prevents ingredients from clumping and ensures consistent capsule filling. Also provides minor nutritional benefits as an essential amino acid.
- Olive Oil: High-quality oil included to support absorption of berberine and other fat-soluble compounds. Olive oil may enhance bioavailability and provides additional antioxidant benefits from its natural polyphenol content.
Key Benefits of This Formula:
- Supports Healthy Blood Sugar Balance: Helps maintain glucose levels already within normal range*
- Promotes Cardiovascular Health: Supports healthy cholesterol and heart function*
- Supports Metabolic Function: Activates AMPK for metabolic optimization*
- May Support Weight Management: Helps maintain healthy metabolism when combined with diet and exercise*
- Supports Gut Health: Promotes healthy microbiome balance*
- Provides Antioxidant Benefits: Helps protect cells from oxidative stress*
- Dual-Standardized Formula: Combines 97% and 8% extracts for comprehensive support*
- Vegetarian-Friendly: Uses vegetable capsules, suitable for most dietary preferences*
Why Choose Nexus Berberine?
Pharmaceutical-Grade 97% Standardization
Features high-potency 97% berberine hydrochloride extract—among the highest standardization available—ensuring you receive therapeutic levels of the active compound in every serving.
Dual-Extract Synergy
Unique combination of 97% pure extract with 8% broad-spectrum extract from bark and root sources provides both concentrated berberine and supporting alkaloids for comprehensive benefits.
Research-Backed Compound
Berberine is one of the most extensively studied natural supplements with hundreds of clinical trials supporting its metabolic and cardiovascular benefits—not just traditional use but modern scientific validation.
AMPK Activation
Supports activation of AMPK, the "metabolic master switch" that regulates glucose and fat metabolism, energy production, and cellular health—a key mechanism behind berberine's diverse benefits.
Cardiovascular Support
Provides multi-faceted support for heart health including healthy cholesterol levels, endothelial function, and cardiovascular tissue protection.
Vegetarian-Friendly Formula
Uses plant-based vegetable capsules rather than gelatin, making it suitable for vegetarians, vegans, and those avoiding animal products.
Enhanced Absorption
Includes olive oil to support berberine absorption and bioavailability, helping ensure your body can effectively utilize this beneficial compound.
Made in USA
Manufactured in the United States under quality control standards for consistency and purity.
Convenient Two-Capsule Serving
Simple once-daily dosing (two capsules) makes it easy to incorporate into your wellness routine.
How to Use for Optimal Results
Recommended Dosage: As a dietary supplement, adults take two (2) capsules daily.
Optimal Timing: For best results, take with 6-8 oz (177-236ml) of water or as directed by your healthcare professional. Many users prefer taking berberine with meals to support post-meal glucose metabolism and enhance absorption.
Consistency Matters:
- Take at the same time each day to establish routine
- Berberine works gradually—commit to at least 8-12 weeks of consistent use
- Benefits build over time as berberine supports metabolic pathways
- Most users notice improvements in energy and well-being within 2-4 weeks, with optimal metabolic benefits developing over 2-3 months
Hydration: Always take with adequate water (6-8oz minimum) to support proper absorption and minimize potential digestive sensitivity.
Duration: Safe for long-term daily use when taken as directed. Many users incorporate berberine as an ongoing part of their wellness routine.
Usage Tips for Maximum Benefits
- Take with Meals: Berberine is best absorbed when taken with food. Taking with meals also supports post-meal glucose metabolism and may minimize any mild digestive effects.
- Divide Dosing if Sensitive: If you experience digestive sensitivity, consider splitting your dose—take one capsule with breakfast and one with dinner rather than both at once.
- Stay Consistent: Set a daily reminder or keep berberine with your meals as a visual cue. Consistency is more important than perfect timing.
- Support with Lifestyle: Maximize berberine's benefits by maintaining a balanced diet rich in whole foods, engaging in regular physical activity, managing stress, and getting adequate sleep.
- Monitor Your Progress: If using berberine to support specific health metrics (blood sugar, cholesterol), work with your healthcare provider to monitor levels and track improvements over time.
- Pair with Probiotics: Since berberine affects gut microbiome, consider taking a quality probiotic supplement (at a different time of day) to maintain healthy bacterial balance.
- Stay Hydrated: Drink plenty of water throughout the day (at least 8 glasses) to support metabolism and overall wellness.
- Be Patient: Natural supplements work gradually. Allow 8-12 weeks to evaluate full benefits rather than expecting immediate dramatic changes.
- Consult Healthcare Provider: If you have diabetes, take medications (especially metformin or other glucose-lowering drugs), or have medical conditions, discuss berberine use with your healthcare provider before starting.
- Avoid Grapefruit: Grapefruit can interfere with berberine metabolism. Avoid grapefruit and grapefruit juice while taking berberine.
Who Will Benefit from Nexus Berberine?
Our premium berberine supplement is ideal for:
- Individuals Supporting Metabolic Health seeking natural blood sugar support
- Those Monitoring Cholesterol Levels wanting cardiovascular wellness support
- People Managing Weight as part of diet and exercise programs
- Adults Over 40 experiencing age-related metabolic changes
- Those with Family History of metabolic or cardiovascular concerns
- Prediabetic Individuals working to maintain healthy glucose levels (with medical supervision)
- People Seeking AMPK Activation for metabolic optimization
- Gut Health Enthusiasts wanting microbiome balance support
- Fitness Enthusiasts seeking metabolic efficiency and body composition support
- Health-Conscious Adults taking proactive approach to wellness
- Those Reducing Sugar Intake wanting additional metabolic support
- Individuals with Metabolic Syndrome Risk Factors (with healthcare guidance)
- People Wanting Research-Backed Supplements preferring scientifically validated compounds
For adult use only. Not suitable for children under 18, pregnant women, or nursing mothers. Those with medical conditions or taking medications should consult healthcare providers before use.
Understanding Key Ingredients
Berberine Hydrochloride
Berberine is a bioactive alkaloid compound extracted from several plants including Berberis species (barberry), Coptis chinensis (goldthread), Hydrastis canadensis (goldenseal), and Berberis aristata (tree turmeric). It has been used for thousands of years in Traditional Chinese Medicine and Ayurvedic medicine for various health purposes. The distinctive yellow color of berberine-containing plants made them valuable as natural dyes historically.
Modern scientific research has extensively validated berberine's health benefits, with over 4,000 published studies investigating its mechanisms and effects. Berberine's primary mechanism involves activating AMPK (AMP-activated protein kinase), an enzyme that acts as a "metabolic master switch" regulating energy metabolism, glucose uptake, fat burning, and cellular health. This AMPK activation is similar to the mechanism of metformin, a common diabetes medication, though berberine is a natural compound.
Research demonstrates berberine's multiple mechanisms for supporting metabolic health:
- Improves insulin sensitivity at the cellular level
- Decreases glucose production in the liver
- Increases glycolysis (breakdown of glucose inside cells)
- Slows carbohydrate breakdown in the gut
- Supports healthy gut microbiome composition
- Activates brown adipose tissue for fat burning
- Reduces inflammation markers
- Provides antioxidant protection
For cardiovascular health, studies show berberine supports healthy cholesterol by:
- Upregulating LDL receptors in the liver
- Inhibiting PCSK9, a protein that degrades LDL receptors
- Reducing cholesterol synthesis
- Supporting healthy triglyceride metabolism
- Protecting endothelial function
Berberine's bioavailability is relatively low (less than 5% absorption), which is why high-potency extracts and supporting ingredients like olive oil are important for effectiveness. Despite low bioavailability, berberine still demonstrates significant benefits, likely due to its effects on the gut microbiome and local intestinal absorption.
Dual Standardization Approach
Our formula uniquely combines two berberine extracts:
97% Extract: Provides high-concentration pure berberine hydrochloride for therapeutic dosing. This pharmaceutical-grade standardization ensures consistent levels of the active compound responsible for metabolic benefits.
8% Extract: Offers a broader spectrum extract containing berberine plus supporting alkaloids (including palmatine, jatrorrhizine, and others) and phytonutrients naturally present in bark and root sources. This "whole plant approach" may enhance effectiveness through synergistic actions.
This combination provides both the proven benefits of concentrated berberine and the potential advantages of full-spectrum plant compounds working together as nature intended.
Quality & Safety Information
Made in USA: Manufactured in the United States under quality control standards.
For Adult Use Only: This supplement is formulated for adults and is not intended for children under 18 years of age.
Important Safety Information:
- Do not exceed recommended dose of 2 capsules daily
- Pregnant or nursing mothers should NOT use this product
- Children under 18 should not use this product
- Individuals with known medical conditions must consult physician before use
- Those taking medications should consult healthcare provider—berberine may interact with various drugs
- Keep out of reach of children
- Do not use if safety seal is damaged or missing
- Store in a cool, dry place away from direct sunlight
Critical Medical Considerations:
- Diabetes/Blood Sugar Medications: Berberine may lower blood sugar. If taking diabetes medications (metformin, insulin, sulfonylureas, etc.), consult your doctor before use as dosage adjustments may be needed. Monitor blood sugar closely.
- Cholesterol Medications: May interact with statins and other cholesterol drugs. Consult healthcare provider.
- Blood Pressure Medications: Berberine may affect blood pressure. Consult healthcare provider if taking antihypertensive medications.
- Anticoagulants: May affect blood clotting. Consult healthcare provider if taking warfarin or other blood thinners.
- Immunosuppressants: Berberine may interact with cyclosporine and other immunosuppressive drugs.
- Cytochrome P450 Substrates: Berberine inhibits CYP3A4 and other enzymes, potentially affecting metabolism of many medications.
Potential Side Effects: Generally well-tolerated, but some individuals may experience:
- Mild digestive upset, gas, or cramping (usually temporary)
- Diarrhea or constipation (taking with food helps)
- Rarely: headache or low blood sugar if taking with other glucose-lowering compounds
Contraindications:
- Pregnancy and breastfeeding
- Children
- Severe liver or kidney disease
- Upcoming surgery (discontinue 2 weeks prior)
- Low blood pressure (hypotension)
Product Specifications
- Capsule Count: 60 capsules per bottle
- Servings Per Container: 30 servings
- Serving Size: 2 capsules
- Gross Weight: 0.2 lb / 90g
- Form: Vegetable capsules
- Capsule Type: Vegetarian cellulose
- Manufacturing Country: USA
Scientific References
While specific product claims are not made, the following research supports the metabolic and cardiovascular benefits of berberine:
- Berberine and Blood Sugar: Yin J, Xing H, Ye J. "Efficacy of berberine in patients with type 2 diabetes mellitus." Metabolism. 2008;57(5):712-717. https://pubmed.ncbi.nlm.nih.gov/18442638/
- Berberine and Cholesterol: Kong W, et al. "Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins." Nature Medicine. 2004;10(12):1344-1351. https://pubmed.ncbi.nlm.nih.gov/15531889/
- Berberine AMPK Activation: Lee YS, et al. "Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states." Diabetes. 2006;55(8):2256-2264. https://pubmed.ncbi.nlm.nih.gov/16873688/
- Berberine and Weight: Zhang Y, et al. "Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine." Journal of Clinical Endocrinology & Metabolism. 2008;93(7):2559-2565. https://pubmed.ncbi.nlm.nih.gov/18397984/
- Berberine and Gut Microbiome: Zhang X, et al. "Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats." PLoS One. 2012;7(8):e42529. https://pubmed.ncbi.nlm.nih.gov/22880019/
- Comprehensive Berberine Review: Imenshahidi M, Hosseinzadeh H. "Berberine and barberry (Berberis vulgaris): A clinical review." Phytotherapy Research. 2019;33(3):504-523. https://pubmed.ncbi.nlm.nih.gov/30556613/
Note: These references are provided for educational purposes regarding berberine research. Individual results may vary.
Frequently Asked Questions
REQUIRED FDA/FTC DISCLAIMER:
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for educational purposes only and is not intended as a substitute for advice from your physician or other healthcare professional. You should not use this information for self-diagnosis or for treating a health problem or disease. If you have or suspect you have a health problem, consult your healthcare provider. Individual results may vary. Always consult with a qualified healthcare professional before starting any diet, exercise, or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. This product may interact with medications including but not limited to diabetes medications, blood pressure medications, cholesterol medications, blood thinners, and others. Berberine may lower blood sugar—those with diabetes or taking glucose-lowering medications must consult their healthcare provider before use and monitor blood sugar levels closely. Not for use by pregnant or nursing women, children under 18, or individuals with liver or kidney disease without medical supervision.
Important Safety & Usage Warning:
Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Keep out of reach of children. Store in a cool, dry place.
Disclaimer:*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for educational purposes only and is not intended as a substitute for advice from your physician or other healthcare professional. You should not use this information for self-diagnosis or for treating a health problem or disease. If you have or suspect you have a health problem, consult your healthcare provider. Individual results may vary. Always consult with a qualified healthcare professional before starting any diet, exercise, or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. This product may interact with medications including but not limited to diabetes medications, blood pressure medications, cholesterol medications, blood thinners, and others. Berberine may lower blood sugar—those with diabetes or taking glucose-lowering medications must consult their healthcare provider before use and monitor blood sugar levels closely. Not for use by pregnant or nursing women, children under 18, or individuals with liver or kidney disease without medical supervision.
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Trimora Diet Drops Ultra | African Mango & Amino Acid Complex | Liquid Dietary Supplement | 1 oz (30ml)
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Trimora Diet Drops Ultra | African Mango & Amino Acid Complex | Liquid Dietary Supplement | 1 oz (30ml)
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Slumbra Sleep Formula | Valerian, Melatonin & GABA Blend | Dietary Supplement to Support Restful Sleep | 60 Count*
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Provenix Prostate Support | Saw Palmetto, Pygeum & Pumpkin Seed | Prostate Wellness Formula | Capsules | 60 Count
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Elastiva C Grass-Fed Collagen Powder, Chocolate Flavor | Types I & III Hydrolyzed Protein | For Skin, Hair & Joint Wellness
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Statements found on this website have not been evaluated by the Food and Drug Administration.
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